KEGG   DRUG: Adefovir dipivoxil
Entry
D01655                      Drug                                   
Name
Adefovir dipivoxil (USAN);
Adefovir pivoxil (JAN);
Hepsera (TN)
Product
  Generic
ADEFOVIR DIPIVOXIL (Apotex Corp.), ADEFOVIR DIPIVOXIL (Sigmapharm Laboratories)
Formula
C20H32N5O8P
Exact mass
501.1989
Mol weight
501.4705
Structure
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
Remark
ATC code: J05AF08
Chemical structure group: DG01224
Product (DG01224): D01655<US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
Hepatitis B [DS:H00412]
Comment
Active form of prodrug: Adefovir [DR:D02768]
Target
HBV reverse transcriptase [KO:K21037]
  Pathway
ko03230  Viral genome structure
ko03240  Viral replication
ko05161  Hepatitis B
Structure map
map07044  Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF08 Adefovir dipivoxil
      D01655  Adefovir dipivoxil (USAN) <US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Adefovir
    D01655  Adefovir dipivoxil (USAN)
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   DG01224  Adefovir
    D01655  Adefovir dipivoxil
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D01655  Adefovir dipivoxil (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01655
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01655
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01655
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01655
Prodrugs [br08324.html]
 D01655
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   DG01224  Adefovir
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    DG01224  Adefovir
Other DBs
CAS: 142340-99-6
PubChem: 7848718
ChEBI: 31175
LigandBox: D01655
NIKKAJI: J592.477D
KCF data

ATOM        34
            1   C8y C    29.9600  -16.0300
            2   C8y C    29.9600  -14.5600
            3   N4y N    28.6300  -16.4500
            4   N5x N    31.1500  -16.6600
            5   N5x N    28.6300  -14.1400
            6   C8y C    31.1500  -13.9300
            7   C8x C    27.7900  -15.3300
            8   C8x C    32.3400  -16.0300
            9   N5x N    32.3400  -14.5600
            10  N1a N    31.1500  -12.5300
            11  C1b C    28.6300  -17.8500
            12  C1b C    27.3700  -18.5500
            13  O2a O    26.1800  -17.8500
            14  C1b C    24.9200  -18.5500
            15  P1b P    23.7300  -17.8500
            16  O2b O    22.5400  -17.1500
            17  O2b O    23.0300  -19.0400
            18  O3b O    24.4300  -16.6600
            19  C1b C    22.5400  -15.7500
            20  O7a O    21.3500  -15.0500
            21  C7a C    20.1600  -15.7500
            22  C1d C    18.9700  -15.0500
            23  C1b C    23.0300  -20.4400
            24  O7a O    21.8092  -21.1430
            25  O6a O    20.1600  -17.1500
            26  C1a C    17.7800  -14.3500
            27  C1a C    19.6700  -13.7900
            28  C1a C    18.2700  -16.2400
            29  C7a C    20.6459  -20.4401
            30  C1d C    19.4251  -21.1431
            31  O6a O    20.6335  -19.0384
            32  C1a C    18.2043  -21.8461
            33  C1a C    20.1281  -22.3639
            34  C1a C    18.7221  -19.9223
BOND        35
            1     2   5 1
            2     2   6 1
            3     3   7 1
            4     4   8 2
            5     6   9 2
            6     5   7 2
            7     8   9 1
            8     1   2 2
            9     1   3 1
            10    1   4 1
            11    6  10 1
            12    3  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   15  17 1
            19   15  18 2
            20   16  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   17  23 1
            25   23  24 1
            26   21  25 2
            27   22  26 1
            28   22  27 1
            29   22  28 1
            30   24  29 1
            31   29  30 1
            32   29  31 2
            33   30  32 1
            34   30  33 1
            35   30  34 1

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Ontology (9)   
   KEGG BRITE (9)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
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Chemical substance (4)   
   PubChem (1)   
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   HMDB (1)   
   NIKKAJI (1)   
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